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Lousy/Intensive Metabolizers, CYP2D6 The formation with the active metabolite, M1, is mediated by CYP2D6, a polymorphic enzyme. Close to 7% with the populace has minimized exercise of your CYP2D6 isoenzyme of cytochrome P450 metabolizing enzyme procedure. These individuals are “very poor metabolizers” of debrisoquine, dextromethorphan and tricy